The nurse is preparing to administer the calcium channel blocker verapamil to a patient. The nurse knows which of the following are correct? Select all that apply.
Select one or more:
a. Significant net effect on cardiac performance.
b. Overdose can produce severe hypotension and cardiotoxicity (bradycardia, AV block).
c. Grapefruit juice can inhibit the intestinal and hepatic metabolism of many drugs and, thus, raise their levels.
d. Therapeutically used to treat angina pectoris, essential hypertension, and cardiac dysrhythmias.