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(a) Describe how C. parvum obtains the glucose it needs for glycolysis after it has infected another cell.
(b) Explain the role of lactate dehydrogenase in enabling C. parvum to continue producing ATP by glycolysis.
(c) Identify the independent variable used in the experiment.
(d) Identify the difference between the control cells and the experimental cells used in the experiment.
(e) Justify the use of a control in this experiment.
(f) Justify the researchers using a different range of concentrations for FX11 than was used for gossypol.
(g) Based on the data in Figure 1, Identify the concentration of gossypol that reduced C. parvum growth to 50% of that in control cells.
(h) Researchers discovered a strain of C. parvum that expresses a functional variation of the lactate dehydrogenase gene. A DNA sequence comparison showed that the variant differs from the normal sequence in the region that codes for the enzyme’s allosteric site. Predict the effect of FX11 treatment on C. parvum that express this variant of lactase dehydrogenase.
(i) Provide reasoning to support your prediction.
(j) Explain how gossypol and FX11 might be used as drugs to treat C. parvum infections in humans without negatively affecting human cells.

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Answer:

Explanation:

a. Because C. parvum infects the digestive system, they could get glucose from the bloodstream since the digestive system is heavy on glucose.  

b. Lactate dehydrogenase catalyzes the reaction from going to pyruvate to lactic acid and back.

c. The independent variable is the concentration of FX11 and Gossypol.

d. The control cells were the cells getting infected, while the experimental cell was the C Parvum to see how it would grow.

f. The concentration of gossypol all that we do see C parvum growth to 50% of that in the control cells is 15 uM.

h. FX 11 will no longer have affect because The allosteric site shape will change which prohibit affects 11 from bonding to the allosteric site of the active acid. This is due to the fact that non-competitive inhibitors bind to the allosteric site, and changing the code means changing the shape.  The best way for gossypol and FX11 to be used is through swallowing because C parvum affect the digestive track.

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