When an action potential reaches a neuromuscular junction, which of the following will happen first?

Acetylcholine binds to acetylcholinesterase and depolarizes the cell.
Sodium ion gates and potassium ion gates open at the same time.
Acetylcholine enters into the synapse to bond with receptor proteins.
Vesicles containing acetylcholine fuse with the presynaptic membrane.

Respuesta :

The answer is when an action potential reaches a neuromuscular junction, it causes acetylcholine to be released at that synapse. Acetylcholine binds to  nicotinic receptors that are concentrated on the motor endplate, a specialized area of ​​the muscle fiber's postsynaptic membrane.

The best-known synapse  is the one that forms between a spinal motor neuron and a skeletal muscle cell. Historically, it has been studied extensively because it is relatively easy to analyze. However, the basic characteristics of synaptic transmission at the skeletal neuromuscular junction are very similar to the process of synaptic transmission in the central nervous system.

what is neuromuscular junction?

  • Consequently,  understanding  this synapse leads to  understanding  the other. Therefore, we will first discuss the process of synaptic transmission at the skeletal neuromuscular junction.

  • The properties of the synaptic connection at the neuromuscular junction are shown in the figure on the left. Skeletal muscle fibers are innervated by motor neurons, whose cell bodies are located in the anterior horn of the spinal cord.

  • The axon terminal region  gives rise to very fine processes that run the length of the skeletal muscle cells. Along these processes are specialized structures known as synapses. The special synapse that occurs between a spinal motor neuron and a skeletal muscle cell is called the motor  endplate because of its specific structure.

  • The synapse at the neuromuscular junction has three distinctive features of chemical synapses in the nervous system. First, there is a clear separation between the presynaptic and  postsynaptic membranes. The space between the two is called the synaptic cleft.

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