One of the differences between the American Indians and the Spanish explorers was There were fewer explorers than American Indians, but the Spanish had powerful weapons.
De Soto came to Georgia with a relatively small army compared to the American Indians that he encountered when he and his army went further into the North American heartland in search of gold.
De Soto came into conflict with the American Indians as he sought the gold. His army was able to defeat the Native Indians who were thousands in number however because they had better weapons such as guns.
He then used these Natives to try to find gold but wasn't successful till he died around the Mississippi River which he was the first recorded European to have crossed.
In conclusion, one difference between the American Indians and the Spanish explorers was that there were fewer explorers than American Indians, but the Spanish had powerful weapons.
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